Obesity-related glomerulopathy: Mechanisms of development, clinical course
نویسندگان
چکیده
منابع مشابه
Lipid mediators of inflammation in obesity-related glomerulopathy.
The interplay between chronic kidney disease (CKD) and obesity represents the convergence of two of the most common contemporary clinical issues, and is of particular interest and significance in the context of the burden presented by each at present, and the dismal projections associated with both of these conditions for the future. That obesity leads to CKD through its association with other ...
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Obesity-related glomerulopathy (ORG) is morphologically defined as focal segmental glomerulosclerosis and glomerulomegaly. Podocyte hypertrophy and reduced density are related to proteinuria which in a portion of patients is in the nephrotic range and evolvs towards renal failure. This article reviews the pathogenetic mechanisms of podocyte injury or dysfunction and lists new possible antiprote...
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Thyroid dysfunction is related to many kidney diseases. We herein present the case of a 39-year-old woman who exhibited obesity-related glomerulopathy-like pathologic features in combination with hyperthyroidism. She displayed hyperthyroidism in spite of receiving anti-thyroid drug treatment, with massive proteinuria (4.5 g/gCr). A renal biopsy demonstrated glomerular hypertrophy (average diame...
متن کاملLow glomerular density with glomerulomegaly in obesity-related glomerulopathy.
BACKGROUND AND OBJECTIVES Obesity-related glomerulopathy is a secondary form of glomerular disease that may occur in obese individuals. It is histologically characterized by marked glomerulomegaly closely related to glomerular hyperfiltration. This study examined glomerular density (nonsclerotic glomerular number per renal cortical area of biopsy specimen) in patients with obesity-related glome...
متن کاملObesity-related glomerulopathy: body mass index and proteinuria.
BACKGROUND AND OBJECTIVES Obesity-related glomerulopathy (ORG) is an increasing cause of end-stage renal disease, but evidence concerning the effects of treatments is rather limited. This study was aimed at exploring the renoprotective effects of weight loss on patients with ORG. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A total of 63 patients with renal biopsy-proven ORG had food and exe...
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ژورنال
عنوان ژورنال: Terapevticheskii arkhiv
سال: 2017
ISSN: 0040-3660
DOI: 10.17116/terarkh201789697-101